Tea Soon Park, Jeffrey S. Huo, Ann Peters, C. Conover Talbot, Karan Verma, Ludovic Zimmerlin, Ian M. Kaplan, Elias T. Zambidis. ''Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors.'' PLoS ONE, 2012; 7 (8): e42838 DOI: 10.1371/journal.pone.0042838
Wed, 22 Aug 2012
Johns Hopkins scientists have developed a reliable method to turn the clock back on blood cells, restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body.
The work, described in the Aug. 8 issue of the journal Public Library of Science One (PLoS One), is "Chapter Two" in an ongoing effort to efficiently and consistently convert adult blood cells into stem cells that are highly qualified for clinical and research use in place of human embryonic stem cells, says Elias Zambidis, M.D., Ph.D., assistant professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.
"Taking a cell from an adult and converting it all the way back to the way it was when that person was a 6-day-old embryo creates a completely new biology toward our understanding of how cells age and what happens when things go wrong, as in cancer development," Zambidis says...