What is Fibromyalgia? WebMD

Fibromyalgia is a chronic condition that causes disabling pain all over the body -- as well as stiffness and tenderness in muscles, tendons, and joints, experts say. It is most common among women ages 35 to 55.

Although it's one of the most common muscle problems, the cause is a mystery, fibromyalgia researchers say. There is no inflammation or joint damage, as occurs with arthritis. There is no damage to internal body organs, as with rheumatoid conditions like lupus. It is called fibromyalgia syndrome because it is identified by a collection of symptoms.

Indeed, the list of possible fibromyalgia symptoms is a long one:

• Chronic muscle pain
• Muscle spasms or leg cramps
• Sleep problems
• Severe fatigue
• Anxiety
• Depression
• Morning stiffness
• Headaches
• Difficulty concentrating
• Skin sensitivities
• Irritability
• Intestinal problems

But these are also common to liver disease, lupus, Lyme disease, thyroid dysfunction, heart disease, arthritis, degenerative joint disease, chronic fatigue syndrome, irritable bowel syndrome, and other disorders -- and therein lies the difficulty in diagnosing fibromyalgia.

How fibromyalgia develops is also a mystery. "The onset can be fairly abrupt, triggered by a motor vehicle accident or a mishap at work," says Steven Berney, MD, chief of rheumatology at Temple University Health System in Philadelphia. "Very quickly the condition sets in. You feel bruised for the next couple of days, but there's the expectation that whatever is disrupted will heal. When the pain doesn't wear off, it becomes clear something else is going on."

More typically, there is a gradual onset, Berney tells WebMD. "The pain becomes more severe over time. That's more difficult to diagnose. You're looking for something that set this off, and you can't find it."

Fibromyalgia research shows that the disorder seems to run in families. Recent studies show that genetic factors may predispose some people to fibromyalgia. An illness or injury that causes trauma to the body can make subtle fibromyalgia symptoms more apparent -- and more troublesome, according to the National Fibromyalgia Association.

"The pain is very real and markedly impedes their lives," Berney says. "People who were very active become disabled by pain and fatigue. 'I want my life back' becomes the charge."

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